Molecular Subtype Classification Is a Determinant of Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes
Identifieur interne : 004109 ( Main/Exploration ); précédent : 004108; suivant : 004110Molecular Subtype Classification Is a Determinant of Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes
Auteurs : Wenbin Zhou ; Zhongyuan He ; Jialei Xue ; Minghai Wang ; Xiaoming Zha ; Lijun Ling ; Lin Chen ; Shui Wang ; Xiaoan LiuSource :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Previous studies suggested that the molecular subtypes were strongly associated with sentinel lymph node (SLN) status. The purpose of this study was to determine whether molecular subtype classification was associated with non-sentinel lymph nodes (NSLN) metastasis in patients with a positive SLN.
Between January 2001 and March 2011, a total of 130 patients with a positive SLN were recruited. All these patients underwent a complete axillary lymph node dissection. The univariate and multivariate analyses of NSLN metastasis were performed. In univariate and multivariate analyses, large tumor size, macrometastasis and high tumor grade were all significant risk factors of NSLN metastasis in patients with a positive SLN. In univariate analysis, luminal B subgroup showed higher rate of NSLN metastasis than other subgroup (
Except for other factors, molecular subtype classification was a determinant of NSLN metastasis in patients with a positive SLN. The predictive accuracy of mathematical models including molecular subtype should be determined in the future.
Url:
DOI: 10.1371/journal.pone.0035881
PubMed: 22563412
PubMed Central: 3338552
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004435
- to stream Pmc, to step Curation: 004434
- to stream Pmc, to step Checkpoint: 002880
- to stream Ncbi, to step Merge: 004D43
- to stream Ncbi, to step Curation: 004D43
- to stream Ncbi, to step Checkpoint: 004D43
- to stream Main, to step Merge: 004123
- to stream Main, to step Curation: 004109
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Subtype Classification Is a Determinant of Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes</title><author><name sortKey="Zhou, Wenbin" sort="Zhou, Wenbin" uniqKey="Zhou W" first="Wenbin" last="Zhou">Wenbin Zhou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="He, Zhongyuan" sort="He, Zhongyuan" uniqKey="He Z" first="Zhongyuan" last="He">Zhongyuan He</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Xue, Jialei" sort="Xue, Jialei" uniqKey="Xue J" first="Jialei" last="Xue">Jialei Xue</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Minghai" sort="Wang, Minghai" uniqKey="Wang M" first="Minghai" last="Wang">Minghai Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zha, Xiaoming" sort="Zha, Xiaoming" uniqKey="Zha X" first="Xiaoming" last="Zha">Xiaoming Zha</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ling, Lijun" sort="Ling, Lijun" uniqKey="Ling L" first="Lijun" last="Ling">Lijun Ling</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Shui" sort="Wang, Shui" uniqKey="Wang S" first="Shui" last="Wang">Shui Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Xiaoan" sort="Liu, Xiaoan" uniqKey="Liu X" first="Xiaoan" last="Liu">Xiaoan Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22563412</idno><idno type="pmc">3338552</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338552</idno><idno type="RBID">PMC:3338552</idno><idno type="doi">10.1371/journal.pone.0035881</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">004435</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004435</idno><idno type="wicri:Area/Pmc/Curation">004434</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004434</idno><idno type="wicri:Area/Pmc/Checkpoint">002880</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002880</idno><idno type="wicri:Area/Ncbi/Merge">004D43</idno><idno type="wicri:Area/Ncbi/Curation">004D43</idno><idno type="wicri:Area/Ncbi/Checkpoint">004D43</idno><idno type="wicri:Area/Main/Merge">004123</idno><idno type="wicri:Area/Main/Curation">004109</idno><idno type="wicri:Area/Main/Exploration">004109</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Subtype Classification Is a Determinant of Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes</title><author><name sortKey="Zhou, Wenbin" sort="Zhou, Wenbin" uniqKey="Zhou W" first="Wenbin" last="Zhou">Wenbin Zhou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="He, Zhongyuan" sort="He, Zhongyuan" uniqKey="He Z" first="Zhongyuan" last="He">Zhongyuan He</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Xue, Jialei" sort="Xue, Jialei" uniqKey="Xue J" first="Jialei" last="Xue">Jialei Xue</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Minghai" sort="Wang, Minghai" uniqKey="Wang M" first="Minghai" last="Wang">Minghai Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zha, Xiaoming" sort="Zha, Xiaoming" uniqKey="Zha X" first="Xiaoming" last="Zha">Xiaoming Zha</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ling, Lijun" sort="Ling, Lijun" uniqKey="Ling L" first="Lijun" last="Ling">Lijun Ling</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Shui" sort="Wang, Shui" uniqKey="Wang S" first="Shui" last="Wang">Shui Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Xiaoan" sort="Liu, Xiaoan" uniqKey="Liu X" first="Xiaoan" last="Liu">Xiaoan Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Previous studies suggested that the molecular subtypes were strongly associated with sentinel lymph node (SLN) status. The purpose of this study was to determine whether molecular subtype classification was associated with non-sentinel lymph nodes (NSLN) metastasis in patients with a positive SLN.</p></sec><sec><title>Methodology and Principal Findings</title><p>Between January 2001 and March 2011, a total of 130 patients with a positive SLN were recruited. All these patients underwent a complete axillary lymph node dissection. The univariate and multivariate analyses of NSLN metastasis were performed. In univariate and multivariate analyses, large tumor size, macrometastasis and high tumor grade were all significant risk factors of NSLN metastasis in patients with a positive SLN. In univariate analysis, luminal B subgroup showed higher rate of NSLN metastasis than other subgroup (<italic>P</italic> = 0.027). When other variables were adjusted in multivariate analysis, the molecular subtype classification was a determinant of NSLN metastasis. Relative to triple negative subgroup, both luminal A (<italic>P</italic> = 0.047) and luminal B (<italic>P</italic> = 0.010) subgroups showed a higher risk of NSLN metastasis. Otherwise, HER2 over-expression subgroup did not have a higher risk than triple negative subgroup (<italic>P</italic> = 0.183). The area under the curve (AUC) value was 0.8095 for the Cambridge model. When molecular subtype classification was added to the Cambridge model, the AUC value was 0.8475.</p></sec><sec><title>Conclusions</title><p>Except for other factors, molecular subtype classification was a determinant of NSLN metastasis in patients with a positive SLN. The predictive accuracy of mathematical models including molecular subtype should be determined in the future.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Veronesi, U" uniqKey="Veronesi U">U Veronesi</name></author><author><name sortKey="Paganelli, G" uniqKey="Paganelli G">G Paganelli</name></author><author><name sortKey="Viale, G" uniqKey="Viale G">G Viale</name></author><author><name sortKey="Luini, A" uniqKey="Luini A">A Luini</name></author><author><name sortKey="Zurrida, S" uniqKey="Zurrida S">S Zurrida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keshtgar, Mr" uniqKey="Keshtgar M">MR Keshtgar</name></author><author><name sortKey="Ell, Pj" uniqKey="Ell P">PJ Ell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lyman, Gh" uniqKey="Lyman G">GH Lyman</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Somerfield, Mr" uniqKey="Somerfield M">MR Somerfield</name></author><author><name sortKey="Benson, Ab" uniqKey="Benson A">AB Benson</name></author><author><name sortKey="Bodurka, Dc" uniqKey="Bodurka D">DC Bodurka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, Wb" uniqKey="Zhou W">WB Zhou</name></author><author><name sortKey="Liu, Xa" uniqKey="Liu X">XA Liu</name></author><author><name sortKey="Dai, Jc" uniqKey="Dai J">JC Dai</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morton, Dl" uniqKey="Morton D">DL Morton</name></author><author><name sortKey="Cochran, Aj" uniqKey="Cochran A">AJ Cochran</name></author><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author><author><name sortKey="Elashoff, R" uniqKey="Elashoff R">R Elashoff</name></author><author><name sortKey="Essner, R" uniqKey="Essner R">R Essner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hack, Tf" uniqKey="Hack T">TF Hack</name></author><author><name sortKey="Cohen, L" uniqKey="Cohen L">L Cohen</name></author><author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name></author><author><name sortKey="Robson, Ls" uniqKey="Robson L">LS Robson</name></author><author><name sortKey="Goss, P" uniqKey="Goss P">P Goss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weaver, Dl" uniqKey="Weaver D">DL Weaver</name></author><author><name sortKey="Krag, Dn" uniqKey="Krag D">DN Krag</name></author><author><name sortKey="Ashikaga, T" uniqKey="Ashikaga T">T Ashikaga</name></author><author><name sortKey="Harlow, Sp" uniqKey="Harlow S">SP Harlow</name></author><author><name sortKey="O Connell, M" uniqKey="O Connell M">M O'Connell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Rr" uniqKey="Turner R">RR Turner</name></author><author><name sortKey="Ollila, Dw" uniqKey="Ollila D">DW Ollila</name></author><author><name sortKey="Krasne, Dl" uniqKey="Krasne D">DL Krasne</name></author><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cady, B" uniqKey="Cady B">B Cady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moghaddam, Y" uniqKey="Moghaddam Y">Y Moghaddam</name></author><author><name sortKey="Falzon, M" uniqKey="Falzon M">M Falzon</name></author><author><name sortKey="Fulford, L" uniqKey="Fulford L">L Fulford</name></author><author><name sortKey="Williams, Nr" uniqKey="Williams N">NR Williams</name></author><author><name sortKey="Keshtgar, Mr" uniqKey="Keshtgar M">MR Keshtgar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cserni, G" uniqKey="Cserni G">G Cserni</name></author><author><name sortKey="Burzykowski, T" uniqKey="Burzykowski T">T Burzykowski</name></author><author><name sortKey="Vinh Hung, V" uniqKey="Vinh Hung V">V Vinh-Hung</name></author><author><name sortKey="Kocsis, L" uniqKey="Kocsis L">L Kocsis</name></author><author><name sortKey="Boross, G" uniqKey="Boross G">G Boross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reynolds, C" uniqKey="Reynolds C">C Reynolds</name></author><author><name sortKey="Mick, R" uniqKey="Mick R">R Mick</name></author><author><name sortKey="Donohue, Jh" uniqKey="Donohue J">JH Donohue</name></author><author><name sortKey="Grant, Cs" uniqKey="Grant C">CS Grant</name></author><author><name sortKey="Farley, Dr" uniqKey="Farley D">DR Farley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Zee, Kj" uniqKey="Van Zee K">KJ Van Zee</name></author><author><name sortKey="Manasseh, Dm" uniqKey="Manasseh D">DM Manasseh</name></author><author><name sortKey="Bevilacqua, Jl" uniqKey="Bevilacqua J">JL Bevilacqua</name></author><author><name sortKey="Boolbol, Sk" uniqKey="Boolbol S">SK Boolbol</name></author><author><name sortKey="Fey, Jv" uniqKey="Fey J">JV Fey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pal, A" uniqKey="Pal A">A Pal</name></author><author><name sortKey="Provenzano, E" uniqKey="Provenzano E">E Provenzano</name></author><author><name sortKey="Duffy, Sw" uniqKey="Duffy S">SW Duffy</name></author><author><name sortKey="Pinder, Se" uniqKey="Pinder S">SE Pinder</name></author><author><name sortKey="Purushotham, Ad" uniqKey="Purushotham A">AD Purushotham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohrt, He" uniqKey="Kohrt H">HE Kohrt</name></author><author><name sortKey="Olshen, Ra" uniqKey="Olshen R">RA Olshen</name></author><author><name sortKey="Bermas, Hr" uniqKey="Bermas H">HR Bermas</name></author><author><name sortKey="Goodson, Wh" uniqKey="Goodson W">WH Goodson</name></author><author><name sortKey="Wood, Dj" uniqKey="Wood D">DJ Wood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwang, Rf" uniqKey="Hwang R">RF Hwang</name></author><author><name sortKey="Krishnamurthy, S" uniqKey="Krishnamurthy S">S Krishnamurthy</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author><author><name sortKey="Mirza, N" uniqKey="Mirza N">N Mirza</name></author><author><name sortKey="Ames, Fc" uniqKey="Ames F">FC Ames</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degnim, Ac" uniqKey="Degnim A">AC Degnim</name></author><author><name sortKey="Reynolds, C" uniqKey="Reynolds C">C Reynolds</name></author><author><name sortKey="Pantvaidya, G" uniqKey="Pantvaidya G">G Pantvaidya</name></author><author><name sortKey="Zakaria, S" uniqKey="Zakaria S">S Zakaria</name></author><author><name sortKey="Hoskin, T" uniqKey="Hoskin T">T Hoskin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perou, Cm" uniqKey="Perou C">CM Perou</name></author><author><name sortKey="Sorlie, T" uniqKey="Sorlie T">T Sorlie</name></author><author><name sortKey="Eisen, Mb" uniqKey="Eisen M">MB Eisen</name></author><author><name sortKey="Van De Rijn, M" uniqKey="Van De Rijn M">M van de Rijn</name></author><author><name sortKey="Jeffrey, Ss" uniqKey="Jeffrey S">SS Jeffrey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gabos, Z" uniqKey="Gabos Z">Z Gabos</name></author><author><name sortKey="Sinha, R" uniqKey="Sinha R">R Sinha</name></author><author><name sortKey="Hanson, J" uniqKey="Hanson J">J Hanson</name></author><author><name sortKey="Chauhan, N" uniqKey="Chauhan N">N Chauhan</name></author><author><name sortKey="Hugh, J" uniqKey="Hugh J">J Hugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weigelt, B" uniqKey="Weigelt B">B Weigelt</name></author><author><name sortKey="Mackay, A" uniqKey="Mackay A">A Mackay</name></author><author><name sortKey="A Hern, R" uniqKey="A Hern R">R A'Hern</name></author><author><name sortKey="Natrajan, R" uniqKey="Natrajan R">R Natrajan</name></author><author><name sortKey="Tan, Ds" uniqKey="Tan D">DS Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reyal, F" uniqKey="Reyal F">F Reyal</name></author><author><name sortKey="Rouzier, R" uniqKey="Rouzier R">R Rouzier</name></author><author><name sortKey="Depont Hazelzet, B" uniqKey="Depont Hazelzet B">B Depont-Hazelzet</name></author><author><name sortKey="Bollet, Ma" uniqKey="Bollet M">MA Bollet</name></author><author><name sortKey="Pierga, Jy" uniqKey="Pierga J">JY Pierga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Wj" uniqKey="Yin W">WJ Yin</name></author><author><name sortKey="Lu, Js" uniqKey="Lu J">JS Lu</name></author><author><name sortKey="Di, Gh" uniqKey="Di G">GH Di</name></author><author><name sortKey="Lin, Yp" uniqKey="Lin Y">YP Lin</name></author><author><name sortKey="Zhou, Lh" uniqKey="Zhou L">LH Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name></author><author><name sortKey="Zhu, L" uniqKey="Zhu L">L Zhu</name></author><author><name sortKey="Jia, W" uniqKey="Jia W">W Jia</name></author><author><name sortKey="Rao, N" uniqKey="Rao N">N Rao</name></author><author><name sortKey="Fan, M" uniqKey="Fan M">M Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolff, Ac" uniqKey="Wolff A">AC Wolff</name></author><author><name sortKey="Hammond, Me" uniqKey="Hammond M">ME Hammond</name></author><author><name sortKey="Schwartz, Jn" uniqKey="Schwartz J">JN Schwartz</name></author><author><name sortKey="Hagerty, Kl" uniqKey="Hagerty K">KL Hagerty</name></author><author><name sortKey="Allred, Dc" uniqKey="Allred D">DC Allred</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millikan, Rc" uniqKey="Millikan R">RC Millikan</name></author><author><name sortKey="Newman, B" uniqKey="Newman B">B Newman</name></author><author><name sortKey="Tse, Ck" uniqKey="Tse C">CK Tse</name></author><author><name sortKey="Moorman, Pg" uniqKey="Moorman P">PG Moorman</name></author><author><name sortKey="Conway, K" uniqKey="Conway K">K Conway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdessalam, Sf" uniqKey="Abdessalam S">SF Abdessalam</name></author><author><name sortKey="Zervos, Ee" uniqKey="Zervos E">EE Zervos</name></author><author><name sortKey="Prasad, M" uniqKey="Prasad M">M Prasad</name></author><author><name sortKey="Farrar, Wb" uniqKey="Farrar W">WB Farrar</name></author><author><name sortKey="Yee, Ld" uniqKey="Yee L">LD Yee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahusen, Fd" uniqKey="Rahusen F">FD Rahusen</name></author><author><name sortKey="Torrenga, H" uniqKey="Torrenga H">H Torrenga</name></author><author><name sortKey="Van Diest, Pj" uniqKey="Van Diest P">PJ van Diest</name></author><author><name sortKey="Pijpers, R" uniqKey="Pijpers R">R Pijpers</name></author><author><name sortKey="Van Der Wall, E" uniqKey="Van Der Wall E">E van der Wall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nos, C" uniqKey="Nos C">C Nos</name></author><author><name sortKey="Harding Mackean, C" uniqKey="Harding Mackean C">C Harding-MacKean</name></author><author><name sortKey="Freneaux, P" uniqKey="Freneaux P">P Freneaux</name></author><author><name sortKey="Trie, A" uniqKey="Trie A">A Trie</name></author><author><name sortKey="Falcou, Mc" uniqKey="Falcou M">MC Falcou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrenk, P" uniqKey="Schrenk P">P Schrenk</name></author><author><name sortKey="Konstantiniuk, P" uniqKey="Konstantiniuk P">P Konstantiniuk</name></author><author><name sortKey="Wolfl, S" uniqKey="Wolfl S">S Wolfl</name></author><author><name sortKey="Bogner, S" uniqKey="Bogner S">S Bogner</name></author><author><name sortKey="Haid, A" uniqKey="Haid A">A Haid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scow, Js" uniqKey="Scow J">JS Scow</name></author><author><name sortKey="Degnim, Ac" uniqKey="Degnim A">AC Degnim</name></author><author><name sortKey="Hoskin, Tl" uniqKey="Hoskin T">TL Hoskin</name></author><author><name sortKey="Reynolds, C" uniqKey="Reynolds C">C Reynolds</name></author><author><name sortKey="Boughey, Jc" uniqKey="Boughey J">JC Boughey</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chen, Lin" sort="Chen, Lin" uniqKey="Chen L" first="Lin" last="Chen">Lin Chen</name><name sortKey="He, Zhongyuan" sort="He, Zhongyuan" uniqKey="He Z" first="Zhongyuan" last="He">Zhongyuan He</name><name sortKey="Ling, Lijun" sort="Ling, Lijun" uniqKey="Ling L" first="Lijun" last="Ling">Lijun Ling</name><name sortKey="Liu, Xiaoan" sort="Liu, Xiaoan" uniqKey="Liu X" first="Xiaoan" last="Liu">Xiaoan Liu</name><name sortKey="Wang, Minghai" sort="Wang, Minghai" uniqKey="Wang M" first="Minghai" last="Wang">Minghai Wang</name><name sortKey="Wang, Shui" sort="Wang, Shui" uniqKey="Wang S" first="Shui" last="Wang">Shui Wang</name><name sortKey="Xue, Jialei" sort="Xue, Jialei" uniqKey="Xue J" first="Jialei" last="Xue">Jialei Xue</name><name sortKey="Zha, Xiaoming" sort="Zha, Xiaoming" uniqKey="Zha X" first="Xiaoming" last="Zha">Xiaoming Zha</name><name sortKey="Zhou, Wenbin" sort="Zhou, Wenbin" uniqKey="Zhou W" first="Wenbin" last="Zhou">Wenbin Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004109 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004109 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3338552
|texte= Molecular Subtype Classification Is a Determinant of Non-Sentinel Lymph Node Metastasis in Breast Cancer Patients with Positive Sentinel Lymph Nodes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22563412" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |